Roma's grip on the Coppa Italia is looking precarious after a 3-1 defeat at Torino in the first leg of their last-16 tie but Serie A leaders Inter retain their hopes of a domestic double after a 4-1 triumph at Reggina.
Alvaro Recoba was the star of Torino's victory against the holders. His long-range effort gave them an early lead and although Mancini equalised for Luciano Spalletti's side just before the break, the Uruguayan scored again for the dominant hosts after a fine run and shot. Late on Recoba set up Gianluca Comotto to give Torino a comfortable advantage ahead of next month's return.
Inter are in an even better position after they earned a three-goal cushion against Reggina. Hernan Crespo set them on their way with a 14th-minute goal and 17-year-old Mario Balotelli celebrated his first Inter start by scoring the second just before the half-hour. Leonardo Pettinari pulled one back early in the second half but Santiago Solari swiftly responded and Balotelli struck again four minutes from time.
In Wednesday's other games, Lazio beat Napoli 2-1, with second-half efforts from Lorenzo De Silvestri and Roberto Baronio overturning Samuele Dalla Bona's opener for the visitors, while Palermo drew 0-0 at Udinese.
In the first-leg matches already played, Empoli overcame Juventus 2-1, Cagliari edged past Sampdoria 1-0 and Serie B outfit Ascoli held Fiorentina 1-1.
Newly-crowned World champions AC Milan welcome Catania on Thursday - in the final first leg match.