Klaas Jan Huntelaar will face a Serie A baptism of fire on Saturday evening when he makes his bow in the Milan derby.
The Netherlands forward joined Leonardo's AC Milan this summer from Real Madrid and missed the opening Serie A fixture through suspension.
Unlike city rivals Inter, the Rossoneri enjoyed a fine start to the campaign with two goals from Alexandre Pato firing them to a 2-1 win at Siena.
Now comes what is always one of the biggest matches of the season and Huntelaar cannot wait to get a taste of the atmosphere.
"I couldn't have asked for a more beautiful game for my debut," he said. "It's a derby, a very hard game and it will be great to play this game for the first time.
"We hope to win and play a great match."
Defending champions Inter, who completed the signing of Wesley Sneijder from Real on Friday, will be looking to clinch their first win after dropping two points last week against newly-promoted Bari but will be without their new signing.
The Nerazzurri fans will be in the minority in this derby at the San Siro as they are officially the away team.
Juventus will be boosted by the presence of captain Alessandro Del Piero when they travel to the Eternal City for Sunday's big clash at Roma.
Del Piero missed his team's 1-0 triumph over Chievo with a muscular injury but has recovered and will lead his team onto the pitch at the Stadio Olimpico.
Later on Sunday, Fiorentina host Palermo seeking their first win of the season after a 1-1 draw at Bologna on the opening day.
Lazio have winning momentum on their side as they go up against Chievo in Verona.
Davide Ballardini's men won the Supercoppa Italiana, cruised to a 3-1 aggregate triumph over Elfsborg in the UEFA Europa League play-off and beat Atalanta in their Serie A opener.
Udinese hope in-form striker Antonio Di Natale can maintain his goalscoring form when they travel to Genoa to meet Sampdoria.
Di Natale struck twice as his team secured a point in their 2-2 draw against Parma last weekend.
Genoa beat Roma 3-2 in their opening match of the campaign and coach Gian Piero Gasperini will expect his team to build on that success when they meet Atalanta in Bergamo.
Cagliari were excellent in their home matches last season and the game against Siena marks their first encounter at the Stadio Sant'Elia this term.
The Sardinian outfit won 11 and lost just four of their 19 encounters at home in 2008-09.
Livorno must overcome the loss of striker Alessandro Diamanti, who was sold to West Ham United this week, as they travel south to meet Napoli.
Parma and Catania battle it out at the Stadio Ennio Tardini with both sides' main aim this campaign to avoid the drop.
Saturday's early game sees Bari go into their home game against Bologna inspired by their 1-1 draw at Inter.