Reggina travel to Rome's Stadio Olimpico on Wednesday night knowing that anything but a win against Lazio will see them relegated from Serie A.
The Amaranto are four points from safety with two games remaining following their 2-1 win against Cagliari on Sunday. That result moved Reggina off the foot of the table and also marked the team's first victory at home since November.
But there were few celebrations at the Stadio Oreste Granillo as Torino's win at Napoli and Bologna's late victory over Lecce mean even a draw for Reggina in Rome will all but relegate them.
"There is so much bitterness by how results changed in the last minutes of the other games," said coach Nevio Orlandi. "Had results gone our way we could have climbed to safety.
"But now we must give everything we have in our next two games against Lazio and Siena and hope that other teams slip-up.
"This is the only way we can have hope of defending our status."
The Amaranto have been given little time to prepare for the clash at Lazio, with the game originally scheduled for Sunday but brought forward due to UEFA's requirements for the UEFA Champions League final that will take place in Rome next week.
Reggina President Pasquale Foti knows his club will have their work cut out to remain in the top flight for a seventh season.
"Lazio are a good team and we respect them," he said. "They play good football and will make life difficult for us.
"But considering our position in the standings, my team travel to Rome with only one result in mind, to clinch a win."
Delio Rossi's Lazio go into the encounter on the back of four consecutive league defeats.
The Biancoceleste, who have assured themselves a place in next season's UEFA Europa League by virtue of winning the Coppa Italia, lost 2-0 at Palermo at the weekend and sit mid-table in Serie A.