Inter will meet Sampdoria in the semi-finals of the Coppa Italia after defeating Roma and Udinese respectively in their quarter-finals on Wednesday.
Jose Mourinho's side secured their place in the last four with a 2-1 win over Roma at the San Siro.
Brazilian striker Adriano opened the scoring for Inter after just ten minutes as the Serie A leaders looked to bounce back from their 3-1 defeat at Atalanta on Sunday.
These two sides had met in each of the past four Coppa Italia finals with Roma winning the previous two, and the holders fought their way back, Rodrigo Taddei drawing them level on the hour mark with a powerful drive.
Parity, however, was shortlived as the Nerazzurri grabbed the lead and winner just two minutes later as Zlatan Ibrahimovic acrobatically volleyed home.
Earlier Sampdoria overcame Udinese 4-1 on penalties after a 1-1 draw in Udine to reach the last four.
The visitors broke the deadlock after 55 minutes when new striker Giampaolo Pazzini netted his first goal for the Genoese side.
Udinese drew level from the penalty spot eight minutes later when Italian international Antonio Di Natale converted his spot-kick.
Di Natale missed the chance to win the game for Udinese in normal time when he saw his last-minute penalty hit the post.
Neither side could find a goal in extra-time forcing the game into a dreaded penalty shoot-out and Samp goalkeeper Antonio Mirante proved to be the hero saving efforts from Gaetano D'Agostino and Simone Pepe.
Lazio host Torino on Thursday with the winners meeting either Napoli or Juventus, who play their quarter-final on Wednesday 4 February.
The two-legged semi finals take place in March and April, while the Final will take place on Wednesday 13 May.
Wednesday 21 January
Inter 2-1 Roma
Udinese 1-1 Sampdoria AET (Pens: 1-4)
Thursday 22 January
Lazio v Torino (2000)
Wednesday 4 February
Juventus v Napoli (1945)
First Leg: Wednesday 4 March
Lazio/Torino v Juventus/Napoli
Sampdoria v Inter
Second Legs: Wednesday 22 April
Inter v Sampdoria
Juventus/Napoli v Lazio/Torino
Wednesday 13 May
[Coppa Italia 2008-09 Draw]
Coppa Italia Quarter-Final Review:
[Wednesday 21 January] – [Thursday 22 January] – [Wednesday 4 February]
Source: Sky Sports / Lega Calcio