Serie A leaders Roma will be hoping to regain the winning touch when they travel to Fiorentina on Wednesday in the first midweek round of the season.
The Giallorossi dropped their first points as they were held to a 2-2 draw by Juventus on Sunday, but they will be hoping to get back to winning ways when they face a tough task against the unbeaten Tuscans.
Despite losing their 100% record, Roma coach Luciano Spalletti was delighted with his players. He said: "When I see my players next I will tell them that they played a great game and that they merited the win. I didn't think Juve would find the equaliser but you have to hand it to them, they created three chances and they took advantage."
Inter, who travel to the early leaders on Saturday, have now gone two matches without a win and need to regain confidence when they face Sampdoria at the San Siro.
After kicking off their Champions League group stage campaign with a 1-0 defeat in Istanbul, the Nerazzurri were expected to bounce back against struggling Livorno on Sunday. But they were again below-par with Zlatan Ibrahimovic's two goals rescuing a point for the champions.
Samp have had a mixed start to the season, with a win, a defeat and two draws from their first four games. They were held to a disappointing goalless draw in the Genoa derby and coach Walter Mazzarri will be hoping for a better performance in Milan.
AC Milan haven't hit top gear yet this season and they face another tricky test with a trip to Palermo. Carlo Ancelotti's side have been criticised for not performing in Serie A and concentrating too much on their European ambitions following three consecutive 1-1 draws.
Palermo are yet to win at home this season but their confidence will be high ahead of the encounter after Sunday’s victory in Sardinia against Cagliari.
After two Serie A games without a win, Juventus will be confident of gaining maximum points against struggling Reggina. La Vecchia Signora earned a late point in Rome at the weekend following their first defeat of the season against Udinese.
The Southerners were also beaten by Udinese at the weekend as their winless start to Serie A continued and a win in Turin looks unlikely.
Lazio have had a miserable start to their campaign as they prepare to host Cagliari. A late defeat against Atalanta on Sunday and three draws from their first four Serie A games have piled the pressure on coach Delio Rossi to get a result at the Stadio Olimpico.
Cagliari also had a disappointing result at the weekend, being toppled 1-0 at home by Palermo. However despite only having 4 points this season, the Sardinians have in general been playing good football and will fancy their chances of heaping more misery on the Biancocelesti.
Napoli were brought back down to earth after the 0-0 draw with Empoli. Two stunning victories over Udinese and Sampdoria had the Partenopei brimming with confidence, although they will be confident of getting back to winning ways against bottom-of-the-league Livorno.
Siena will be facing a tough task in their quest to gain their first win of the season against third-placed surprise package Atalanta, while Genoa meet a confident Udinese side, who have picked up two straight wins.
Elsewhere, Catania meet Empoli and Torino visit Parma as all four clubs search for their first Serie A win.