Internazionale will begin the defence of their Serie A title with an away fixture against Bologna when the new Italian season kicks off on the weekend of August 28.
After weeks of anticipation, the fixtures for the 2010-2011 season were drawn on live television in front of a star-studded audience at Milan's Palazzo Mezzanotte this evening.
New Inter boss Rafael Benitez will take his players to the Stadio Renato Dall'Ara as he looks to make a winning start to the domestic season.
Bologna finished 17th in Serie A last term while the Nerazzurri claimed their 18th Scudetti on a dramatic final day of the league campaign, on their way to an unprecedented Italian treble.
But that first game will probably be shifted to August 30, given Inter face UEFA Europa League winners Atletico Madrid in the European Super Cup on August 27.
Roma, who finished runners-up to the Nerazzurri in both the league and in the cup, kick off their season at home to newly-promoted Cesena while new AC Milan coach Massimiliano Allegri begins his reign at home to newcomers Lecce.
Juventus, who suffered a season to forget last term, begin life under Luigi Del Neri at Bari and Sinisa Mihajlovic's Fiorentina welcome Napoli to the Stadio Artemio Franchi on the opening day.
Last season's surprise package Sampdoria host Lazio while Palermo play Cagliari in the Derby della Isole.
Elsewhere, Brescia begin life in the top-flight at Parma, Genoa travel to Udinese and Chievo take on Catania.
Highlights of the season
Inter will visit Roma in their first big test in Week 5 on September 26 (with the return match on February 6) and host traditional rivals Juventus in the Derby d'Italia a week later, on October 3 (February 13).
After those games, the Nerazzurri will play city rivals AC Milan in the Derby della Madonnina in Week 12 on November 14 (April 3), with Juve facing Roma and Palermo meeting Sicilian rivals Catania on the same weekend.
The Derby della Capitale between Lazio and Roma will take place in Week 10 on November 7 (March 13), while the Derby della Lanterna between Sampdoria and Genoa is scheduled for Week 17 on December 19 - the final round before the Winter break (May 8).
The New Year kicks off with the return of the Puglian derby in Serie A, between Lecce and Bari, in Week 18 on January 6.
In other key encounters Milan host Juventus in Week 9 on October 31 (March 6) and Roma in Week 17 on December 19, while Juventus play Fiorentina in Week 14 on November 28 (April 17) and travel to Napoli in Week 19 on January 9 (May 22).
Meanwhile, Juve coach Del Neri welcomes former club Sampdoria in Week 2 on September 12 (January 23), and Milan coach Allegri takes his new club to Cagliari in Week 18.
The final day of the season on May 22 will see Bologna-Bari, Brescia-Fiorentina, Cagliari-Parma, Genoa-Cesena, Inter-Catania, Juventus-Napoli, Lecce-Lazio, Palermo-Chievo, Roma-Sampdoria and Udinese-Milan.
Week 1 Fixtures
28/29/30 August 2010
Bari v Juventus
Bologna v Inter
Chievo v Catania
Fiorentina v Napoli
Milan v Lecce
Palermo v Cagliari
Parma v Brescia
Roma v Cesena
Sampdoria v Lazio
Udinese v Genoa
Complete Fixture List:
[Serie A 2010-11]
Source: Lega Serie A