Sampdoria slipped to a 1-0 defeat against Inter, but still made the final of the Coppa Italia where they will face Lazio.
Jose Mourinho's men trailed 3-0 from the first leg of the semi-final contest and never looked like overturning that deficit.
After a bright start, Samp were made to pay as Inter went ahead through Zlatan Ibrahimovic on the half-hour mark. The Sweden international volleyed home from the edge of the area after latching onto a long ball.
The home side went close to adding a second, and Samp had chances to wrap up the tie and also had a strong penalty appeal waved down in the second half.
Time was running out for the Serie A leaders and their misery was completed in injury-time when Marco Materazzi was shown a second yellow card.
Four-time cup winners Sampdoria and Lazio, who were 4-2 aggregate winners against Juventus on Wednesday, will meet in the final at Rome's Stadio Olimpico on 13 May.
First Leg: Tuesday 3 March
Lazio 2-1 Juventus
First Leg: Wednesday 4 March
Sampdoria 3-0 Inter
Second Leg: Wednesday 22 April
Juventus 1-2 Lazio (Agg: 2-4)
Second Leg: Thursday 23 April
Inter 1-0 Sampdoria (Agg: 1-3)
Wednesday 13 May
Lazio v Sampdoria
[Coppa Italia 2008-09 Draw]
Coppa Italia Semi-Final Second Leg Review:
[Wednesday 22 April] – [Thursday 23 April]
Source: Sky Sports / Lega Calcio