Lazio host Fiorentina on Wednesday looking to bounce back from the weekend debacle at AC Milan.
The Biancoceleste lost 4-1 at the San Siro on Sunday, their first defeat of the season after two consecutive wins had seen them emerge as the early pacesetters in Serie A.
"This is no drama," insisted Lazio coach Delio Rossi. "We need to focus immediately on Wednesdays game.
"We cannot cry over spilt milk."
For a team that had not conceded a goal before Sunday, the result was all the more painful.
However, Rossi preferred to look ahead with optimism. "There were positives that we must take from our game at AC Milan," he said.
"We tried to play without fear, with courage. In the end, you can pay the price for this approach. We need to bounce back from this, starting against Fiorentina.
Just like Lazio's Rossi, Milan coach Carlo Ancelotti is not reading too much into Sunday's result.
The Rossoneri lost their first two games but silenced their critics with their first league victory.
"I don't know if our crisis has ended," said Ancelotti. "But against Lazio we played in attack as we have done for many years. When you have all the players available it's clear that this is the ideal solution.
"We need to continue to play like this."
The Rossoneri will be without injured playmaker Andrea Pirlo when they travel to the Stadio Oreste Granillo for for their midweek clash at Reggina.
Defending champions Inter host Lecce looking to take over the sole leadership of Serie A. The Nerazzurri are level on seven points with Juventus after three games played.
In-form Juve entertain Catania and will have to do without goalkeeper Gianluigi Buffon, who sustained a thigh injury during their 1-0 victory at Cagliari.
The Bianconeri will be hoping Brazilian striker Amauri maintains his excellent form in front of goal.
Amauri struck against both Udinese and Cagliari to earn the club maximum points.
A Francesco Totti-less Roma will try to build on their 3-1 triumph against Reggina, their first success of the campaign, when they make the journey to Genoa.
The Giallorossi will be without veteran playmaker Totti, who has yet to return to full fitness.
Sampdoria travel to Tuscany to meet Siena searching for their first win of the season.
Palermo are aiming for a third consecutive triumph when they make the journey to the San Paolo to meet Napoli.
Luigi Del Neri's Atalanta entertain bottom-side Cagliari hoping to bounce back from Sunday's narrow defeat at Catania.
Bologna have suffered two consecutive defeats and will try to stop the rot at home to Udinese while Chievo are also at home in Verona against Torino.