AC Milan travel to Genoa on Sunday looking to bounce back from their humiliating 2-0 friendly defeat to Swiss second division side Lugano in midweek.
The Rossoneri had to do without several players on international duty but Milan coach Carlo Ancelotti still had a number of stars at his disposal and yet they were brushed aside.
Ancelotti was so upset that he did not speak to reporters after the game. The result followed Milan's 2-1 defeat to Bologna in their Serie A opener.
Milan's Brazil international Ricardo Kaka did play for the first time since having knee surgery in the summer and he said: "It's a pity to have lost this game and given such an image.
"The good news is that I feel well. To have played 45 minutes has done me good and it has made me realise that I don't feel pain.
"I will be available for the game at Genoa but it will be down to the coach to decide whether or not to include me in the team."
Andriy Shevchenko, who scored in Ukraine's 3-1 World Cup qualifying win at Kazakhstan on Wednesday, could start against Genoa with veteran striker Filippo Inzaghi having sustained a muscular injury against Lugano.
Jose Mourinho's Inter host Catania on Saturday night looking for their first league victory after their 1-1 draw at Sampdoria.
Catania fans will not be allowed to travel to the San Siro as the game is considered of high risk.
Juventus coach Claudio Ranieri will be looking for his side to bounce back following their 1-1 draw at Fiorentina when they host Udinese on Sunday night.
Alberto Gilardino's late equaliser gave the Viola a point against Juve.
New Palermo coach Davide Ballardini faces a baptism of fire when his team entertain Roma in Saturday's early game.
Ballardini was appointed following Stefano Colantuono's sacking after his team's season opening 3-1 defeat at Udinese.
Naples' Stadio San Paolo will be half empty with Fiorentina fans banned from travelling to the game while other sections of the stadium will be closed to Napoli fans.
Siena will have to overcome the absence of Massimo Maccarone when they take on Cagliari in Tuscany with the Italian striker banned for three matches.
Lazio welcome back coach Delio Rossi for the clash against Sampdoria at the Stadio Olimpico. Rossi served the third and last game of his touchline ban, that dated back to last season, in his team's 4-1 triumph at Cagliari.
Promoted sides Chievo and Lecce will battle it out at the Stadio Via Del Mare.
Two sides that won their opening games meet when Bologna host Atalanta and Torino will go for a second straight victory when they taken on Reggina in Reggio Calabria.