Palermo President Maurizio Zamparini has parted company with coach Stefano Colantuono after a 5-0 defeat by Juventus, recalling Francesco Guidolin in his place.
"I'm very sorry but these kinds of things happen in football," Colantuono, 45, said.
"I think we were in a good position, with a good chance to qualify for the UEFA Cup, but I don't want to start any kind of argument. This is part of the game. Yesterday we had a very bad day, but I think that happens sometimes."
Colantuono, who arrived from Atalanta last summer, will be replaced by Guidolin for a fourth spell.
The 52-year-old first coached Palermo in 2004/05 and returned last season when he was sacked and reappointed before helping the Rosanero qualify for the UEFA Cup.
Palermo are eighth in Serie A with 18 points from 13 games.
Colantuono is the fifth Coach to receive his marching orders following Marco Giampaolo, Andrea Mandorlini, Massimo Ficcadenti and Fernando Orsi.
Source: C4 Football Italia / UEFA